live entertainment: January 2013

Thursday, January 31, 2013

WSJ and NYT accuse Chinese hackers of infiltrating their newsgathering systems

And the saga continues. Just a year after Bloomberg News was reportedly targeted by Chinese hackers, both The Wall Street Journal and The New York Times have independently published reports suggesting that they too are being probed. Both organizations seem to think that it's all part of a larger scheme, with Chinese hackers sifting through newsgathering systems of outlets that are reporting on touchy subjects. As the Times puts it: "The attacks appear to be part of a broader computer espionage campaign against American news media companies that have reported on Chinese leaders and corporations."

When asked about such a possibility, China's Ministry of National Defense (unsurprisingly) denied the allegations, noting that "to accuse the Chinese military of launching cyberattacks without solid proof is unprofessional and baseless." As it stands, the FBI is already looking into various attacks of this nature, but strangely, the hacking attempts aren't being universally viewed as malicious. Paula Keve, chief spokeswoman for Dow Jones & Co., stated: "Evidence shows that infiltration efforts target the monitoring of the Journal's coverage of China, and are not an attempt to gain commercial advantage or to misappropriate customer information." As you'd expect, both outfits are stepping up security in a major way in hopes of fending off any future attempts.

Filed under: Internet

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Source: The Wall Street Journal, The New York Times

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/KP3vn-V5ArE/

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Wednesday, January 30, 2013

Great Ideas! 8 Hearty Dishes Your Kids Will Love

From roast tomato soup and baked eggs to shrimp and grits, Brooklyn Supper bloggers (and real life couple!) Brian Campbell and Elizabeth Stark share their yummy, easy-to-make recipes.

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/r1bJvBof2Us/

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ShoeDazzle Is Bringing Subscriptions Back, At $9.95 A Month For Free Shipping, Discounts, And Other Perks

The next phase of ShoeDazzle's evolution will involve bringing back one of the founding premises of the e-commerce site: subscriptions. But the company's new subscription plan, which will be rolled out in the coming weeks, varies significantly from its old $39.95 a month plan. It's not only cheaper, at $9.95 a month, but it gives users new perks for participating.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/t8CyuvIYJYY/

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Checking out open access

Public release date: 30-Jan-2013
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Contact: Clea Desjardins
clea.desjardins@concordia.ca
514-848-2424
Concordia University

Concordia librarian looks at how libraries can use technology to keep information free in the digital age

This press release is available in French.

Montreal, January 20, 2013 From Wikipedia to shareware, the Internet has made information and software more widely available than ever. At the heart of this explosion is the simple idea that information should be open and free for anyone. Yet with publishers charging exorbitant fees for subscriptions to academic journals, university libraries are struggling to keep up.

Writing in the Journal of Academic Librarianship, Concordia collections librarian Geoffrey Little says that a key way to meet that challenge is through the use of open source technology. "In order to make information freely available through open access policies, it's important to look beyond traditional and expensive methods of dissemination and turn instead to open source software," he says.

Open source software is non-proprietary software for which source code (the instructions that make computer programs work) and documentation are freely available. "It's an ideal way for libraries to avoid having to pay large amounts of money to commercial vendors for new products or ongoing maintenance and access. The ability play with source codes in order to modify the program also means that tools can be customized to meet a library's needs and the specific community of users," says Little.

Open source technology is already being used in academic libraries across the country. Tools such as archival management software and course management systems rely upon open source software to disseminate information to a wide public. As journal prices continue to increase, new online scholarly journals are being created outside of traditional commercial publishing channels and are hosted independently rather than by an academic press or commercial publisher.

Here at Concordia University, a landmark Senate resolution on open access encourages all faculty and students to make their peer-reviewed research and creative output freely accessible online through an institutional repository, called Spectrum. In fact, Concordia is the first major university in Canada where faculty members have given their overwhelming support to making the results of their research universally available.

Little hopes the infrastructure and support that is necessary to ensure sustainability of the long-term future of open access projects and initiatives can be guaranteed. "Librarians need to be advocates for open access to ensure that institutional support does not evaporate after a few years. Our mission is to help the users of our libraries access resources that will enable them to write their papers, craft their survey instruments and conduct their lab experiments and open access is a big part of that."

"Thinking about our work through a lens of open access and using open source technologies where and when they make sense can help academic librarians in our mission to support the scholarly enterprise," continues Little. "Open access is an audacious and evolving initiative that presents us with a unique set of opportunities and challenges. We should not be afraid to experiment, investigate, and be bold in our thinking about the ways in which we can incorporate open access into our work and mission."

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Cla Desjardins
Senior Advisor, External Communications
Concordia University
Tel: 514-848-2424, ext. 5068
Cell: 514-909-2999
e-mail: clea.desjardins@concordia.ca
Web: concordia.ca/media-relations
Twitter: twitter.com/CleaDesjardins

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Checking out open access

Public release date: 30-Jan-2013
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Share ]

Contact: Clea Desjardins
clea.desjardins@concordia.ca
514-848-2424
Concordia University

Concordia librarian looks at how libraries can use technology to keep information free in the digital age

This press release is available in French.

###

Related links:

Media contact:

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-01/cu-coo013013.php

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Man shot in Alabama school bus incident

By Jeff Black and M. Alex Johnson, NBC News

WSFA.com

Multiple local and county officials were on the scene of the shootng Tuesday, Jan. 29, near Midland City, Ala.

Updated at 12:10 a.m. ET: A man boarded a school bus in southeastern Alabama on Tuesday afternoon, fatally shot the driver and then grabbed a 6-year-old before fleeing, authorities said, according to The Associated Press.?

Authorities said the man took the child to an underground bunker behind a nearby church, according to the AP. Police were negotiating with the suspect late Tuesday evening. WSFA 12 News reported that the child is still with the suspect and is "OK."?

The Dale County Sheriff told WBMA-TV that the man demanded a child be let off the bus with him. When the driver refused, police said, the man shot the driver. The driver died of gunshot wounds. ?

Michael Creel, a neighbor of the suspected shooter, told?The Dothan Eagle?newspaper that his sister heard gunshots so he went outside. He saw children running away from the bus.

A little girl reportedly told Creel that the suspected shooter had come on the bus and demanded that two children ages of 6 to 8 come with him. ?

Multiple agencies, including a bomb unit, were on the scene along a rural highway near Midland City, in the area of Dothan and Ozark, the Dale County Sheriff's Department said.?

School officials said all Dale County and Ozark city schools would be closed Wednesday.

Law enforcement officials closed roads in the area.

It wasn't clear how many children had been on the bus, but Lisa Harden of the Dale County School District told NBC News that it was carrying children of all ages.

The other children were taken to a high school so their parents could pick them up, Harden said. The Eagle reported that at least seven children were seen being taken to nearby vehicles.

NBC staff writer Isolde Raftery contributed reporting.

Source: http://usnews.nbcnews.com/_news/2013/01/29/16759153-man-shot-in-incident-involving-alabama-school-bus-suspect-at-large?lite

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Tuesday, January 29, 2013

Neuroscientists pinpoint location of fear memory in amygdala

Jan. 27, 2013 ? A rustle of undergrowth in the outback: it's a sound that might make an animal or person stop sharply and be still, in the anticipation of a predator. That "freezing" is part of the fear response, a reaction to a stimulus in the environment and part of the brain's determination of whether to be afraid of it.

A neuroscience group at Cold Spring Harbor Laboratory (CSHL) led by Assistant Professor Bo Li Ph.D., together with collaborator Professor Z. Josh Huang Ph.D., have just released the results of a new study that examines the how fear responses are learned, controlled, and memorized. They show that a particular class of neurons in a subdivision of the amygdala plays an active role in these processes.

Locating fear memory in the amygdala

Previous research had indicated that structures inside the amygdalae, a pair of almond-shaped formations that sit deep within the brain and are known to be involved in emotion and reward-based behavior, may be part of the circuit that controls fear learning and memory. In particular, a region called the central amygdala, or CeA, was thought to be a passive relay for the signals relayed within this circuit.

Li's lab became interested when they observed that neurons in a region of the central amygdala called the lateral subdivision, or CeL, "lit up" in a particular strain of mice while studying this circuit.

"Neuroscientists believed that changes in the strength of the connections onto neurons in the central amygdala must occur for fear memory to be encoded," Li says, "but nobody had been able to actually show this."

This led the team to further probe into the role of these neurons in fear responses and furthermore to ask the question: If the central amygdala stores fear memory, how is that memory trace read out and translated into fear responses?

To examine the behavior of mice undergoing a fear test the team first trained them to respond in a Pavlovian manner to an auditory cue. The mice began to "freeze," a very common fear response, whenever they heard one of the sounds they had been trained to fear.

To study the particular neurons involved, and to understand them in relation to the fear-inducing auditory cue, the CSHL team used a variety of methods. One of these involved delivering a gene that encodes for a light-sensitive protein into the particular neurons Li's group wanted to look at.

By implanting a very thin fiber-optic cable directly into the area containing the photosensitive neurons, the team was able to shine colored laser light with pinpoint accuracy onto the cells, and in this manner activate them. This is a technique known as optogenetics. Any changes in the behavior of the mice in response to the laser were then monitored.

A subset of neurons in the central amygdala controls fear expression

The ability to probe genetically defined groups of neurons was vital because there are two sets of neurons important in fear-learning and memory processes. The difference between them, the team learned, was in their release of message-carrying neurotransmitters into the spaces called synapses between neurons. In one subset of neurons, neurotransmitter release was enhanced; in another it was diminished. If measurements had been taken across the total cell population in the central amygdala, neurotransmitter levels from these two distinct sets of neurons would have been averaged out, and thus would not have been detected.

Li's group found that fear conditioning induced experience-dependent changes in the release of neurotransmitters in excitatory synapses that connect with inhibitory neurons -- neurons that suppress the activity of other neurons -- in the central amygdala. These changes in the strength of neuronal connections are known as synaptic plasticity.

Particularly important in this process, the team discovered, were somatostatin-positive (SOM+) neurons. Somatostatin is a hormone that affects neurotransmitter release. Li and colleagues found that fear-memory formation was impaired when they prevent the activation of SOM+ neurons.

SOM+ neurons are necessary for recall of fear memories, the team also found. Indeed, the activity of these neurons alone proved sufficient to drive fear responses. Thus, instead of being a passive relay for the signals driving fear learning and responses in mice, the team's work demonstrates that the central amygdala is an active component, and is driven by input from the lateral amygdala, to which it is connected.

"We find that the fear memory in the central amygdala can modify the circuit in a way that translates into action -- or what we call the fear response," explains Li.

In the future Li's group will try to obtain a better understanding of how these processes may be altered in post-traumatic stress disorder (PTSD) and other disorders involving abnormal fear learning. One important goal is to develop pharmacological interventions for such disorders.

Li says more research is needed, but is hopeful that with the discovery of specific cellular markers and techniques such as optogenetics, a breakthrough can be made.

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The above story is reprinted from materials provided by Cold Spring Harbor Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Haohong Li, Mario A Penzo, Hiroki Taniguchi, Charles D Kopec, Z Josh Huang, Bo Li. Experience-dependent modification of a central amygdala fear circuit. Nature Neuroscience, 2013; DOI: 10.1038/nn.3322

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/lxzF37HaE7w/130128104739.htm

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At a glance: 3 months later, Sandy losses mount (Providence Journal)

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Iran Just Sent a Monkey Into Space

Sky News is reporting that Iran just took a major step towards its goal of achieving manned space flight—by firing a monkey into space. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/FRpAtYxK_3U/iran-just-sent-a-monkey-into-space

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Monday, January 28, 2013

Dow Chemical withdraws from natural gas export project

Dow Chemical publicly disavowed?a $6.5 billion project for a natural gas export terminal that it partly owns, Alic writes.?Dow is opposed to this project because its senior management believes high volumes of LNG exports will lead to higher prices at home.

By Jen Alic,?Guest blogger / January 28, 2013

The liquefied natural gas tanker Inigo Tapias makes its way through Boston Harbor past downtown Boston. Dow Chemical opposes the natural gas export project because its senior management believes high volumes of LNG exports will lead to higher prices at home, Alic writes, which would bode ill for the future construction of chemical plants and Dow?s overall bottom line.

Michael Dwyer/AP/File

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Dow Chemical CO. (NYSE:DOW) is opposed to the idea of unlimited US natural gas exports, and this opposition has led it most recently to completely disown a $6.5 billion project for a Texas export terminal that it partly owns.

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In breast cancer metastasis, researchers identify possible drug target

Jan. 27, 2013 ? The spread of breast cancer to distant organs within the body, an event that often leads to death, appears in many cases to involve the loss of a key protein, according to UC San Francisco researchers, whose new discoveries point to possible targets for therapy.

In the January 27, 2013 online edition of Nature Cell Biology, UCSF scientists describe for the first time how the protein, known as GATA3 -- which is abnormal or absent in many cases of human breast cancer -- normally acts downstream in biochemical pathways to prevent the distant spread of cancer, an event called metastasis.

The discovery points to a biochemical control point that simultaneously holds in check several key events required for tumor cells to successfully spread.

"When GATA3 is present, it turns off many genes that are active in metastasis," said Zena Werb, PhD, a UCSF professor of anatomy who led the research. "We now have identified the molecular mechanisms involved."

The key finding of the new study is that GATA3 acts downstream biochemically to activate a molecule -- obscure until now -- called microRNA29b. MicroRNA29b in turn stops protein production from other genes that play vital roles in metastasis.

The absence or loss of GATA3 can free cancerous cells to break free from their defined roles and tethers within a tumor, to move away from the tumor mass, to induce cancer-promoting inflammation, and to stimulate the development of new blood vessels that can help spreading cancerous cells regrow as tumors in new locations.

"People knew that some of these genes were turned on in some cancers, but they did not know they were turned on because GATA3 and microRNA29b were turned off," Werb said. "If you have 20 genes that are becoming less active all at once due to microRNA29b, it could have a profound effect."

Working with mice, the researchers found that restoring microRNA29b to one of the most deadly types of breast cancer stopped metastasis. But the researchers also found that if they knocked out the microRNA29b, tumors spread even in the presence of GATA3, suggesting that microRNA29b can be the driver of metastasis.

In the mouse models of breast cancer studied by Werb's team, GATA3 normally restrains cancerous cells from breaking away from the main tumor and migrating to other organs.

It might be possible, Werb said, to develop drugs that inhibit breast cancer metastasis by re-activating these controls in cancerous cells that have lost the normal protein.

Many researchers who study early stages of cancer focus on abnormal genes and proteins that cause cells to expand their numbers rapidly, a hallmark of cancer.

However, the ability to spread to distant places and to eventually cause lethal complications requires not only cell division and tumor growth, but also changes in how the cancerous cell negotiates with its surroundings. This relationship must be altered to permit cancer to spread, according to earlier research findings by Werb and others.

"Many of the key processes in cancer that GATA3 suppresses take place outside the cell, in the surrounding environment," she said.

GATA3 is a master control for luminal cells, which line the milk-carrying ducts of the breast. In essence, GATA3 dictates the defining characteristics of a normal breast cell, Werb said.

Luminal breast cancers are the most common form of the disease, and the hormones estrogen and progesterone drive their growth. Loss of the normal GATA3 protein as luminal breast cancers evolve is associated with a greater risk of death, Werb said, and occurs in roughly 10 percent of luminal breast cancer cases.

But, along with many other proteins, GATA3 also is absent in "triple negative," breast cancers, which are more often fatal. Triple negative breast cancers, which disproportionately affect black women and younger women, do not depend on the hormones, nor do they require a third growth factor, called HER2.

Triple negative breast cancers, which account for roughly one-in-five breast cancers, have been more difficult to target successfully with newer treatments.

"The targeting we would like to do is to give back microRNA29b specifically to breast tumor cells to prevent metastasis," Werb said.

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The above story is reprinted from materials provided by University of California - San Francisco, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Jonathan Chou, Jeffrey H. Lin, Audrey Brenot, Jung-whan Kim, Sylvain Provot, Zena Werb. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating?microRNA-29b expression. Nature Cell Biology, 2013; DOI: 10.1038/ncb2672

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/9MKEP8kbDFI/130127134214.htm

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Sunday, January 27, 2013

For Super Bowl ads, it's go viral or go home

4 hrs.

Ben Popken, NBC News contributor

Call them super leaks, super teasers or super previews. But for a growing number of Super Bowl advertisers, they are super smart business.

For years, Super Bowl commercials were closely guarded secrets until they aired on the biggest ratings day of the year. These days, companies have discovered that teasing them online in advance of the big day is a more efficient way of getting their brand message in front of the masses.

CBS, which will broadcast Super Bowl XLVII on?Feb. 3, sold 30-second ad slots for up to $4 million, so it?s no wonder advertisers try to squeeze every drop of value out of their investment.

"We are seeing more teasers because they have been effective," said?Steve Posavac, professor of marketing at Vanderbilt University. "This year, many advertisers feel that if they don?t release a teaser, they will fail to gain consumers? mindshare, and that their ads will be lost in the clutter."

Mercedes-Benz roared out of the starting line first last week, with its spot featuring Kate Upton. Strutting in daisy dukes and a low cut tank top, the striking supermodel blows suds in slow motion at a group of guys as they wash her Benz and ogle her frame, mouths agape.

Though it shows less skin than a standard shampoo commercial -- and seems demure in comparison to?Upton's past backseat turn for Carl's Jr.?last year ? it has already drummed up plenty of buzz. As of Friday night, the teaser racked has up more than 4.6 million YouTube views.

That?s right, more than a week before the San Francisco 49ers face the Baltimore Ravens, Mercedes-Benz?s ad is already a success. And, thanks to the Parents? Television Council, we have the first Super Bowl controversy.

"This ad [reinforces] for millions of wives, daughters and sisters across the country that you use your sex appeal to get what you want," a Parents' Television Council spokesperson told the Daily Mail, complaining that the ad "isn't selling cars, it?s selling sexual objectification."

The sound bite provided global media outlets (ours included) the perfect news hook. In the following days, the ad has been discussed, analyzed, and played over and over again, at no cost to the Mercedes. Talk about return on investment!

The luxury German automaker isn?t the only player in this game. Coca-Cola, Sketchers, Wonderful Pistachios (with 'Gagngam Style' superstar Psy) and MiO (with Tracy Morgan) have released previews.

Coke is also making a huge social media play with its "Mirage" campaign. In it, three quirky character-driven groups -- show girls, badlanders, and cowboys -- race across an African desert to be the first to reach the thirst-quenching Coca-Cola oasis. A preview spot is circulating online encouraging viewers to vote online to determine which group ends up winning in the final spot. Online surfers can either vote by "old-fashioned" online button clicking, or vote-casting with the Twitter hashtags #CokeCowboys, #CokeShowgirls and #CokeBadlanders.

The beverage giant?s advertising company has also cooked up animated gifs, "sabotage videos" and other content ready-made for Tweeting, Tumbling, Instagramming, and Facebooking.?

Indeed,?Coke?has come a long way from Mean Joe Greene?s jersey toss in Coke?s legendary commercial 34 years ago.

The reason for the big social push is simple: More shares equal more views, which equals more brand exposure.

"Without a social media component, a Super Bowl ad is worthless," said?David Johnson, CEO of public relations agency Strategic Vision.

Social has risen and advertisers are rising to meet it.

"Three quarters of the audience will be on a 'second screen' during the Super Bowl,? said Ankarino Lara, chief product officer for Thismoment, which builds branded online content distribution software. "The biggest brands recognize the audience shift and plan mobile and on live elements in their campaigns."

According to data by the Unruly Viral Video Chart, the "Billboard 100 of viral videos," 75 percent of the top 20 most-shared ads from Super Bowl 2012 went up online before game day;? 55 percent of sharing happened after March 1, 2012; and total Super Bowl ads shares increased by 129 percent from 2011 to 2012.

Audi is taking a similar "choose your own adventure" approach as Coke's. On Thursday night, it posted the beginning of its ad, showing a kid driving to his high school prom dateless but in his dad's new 2013 Audi S6 high-performance sports sedan. The German automaker also uploaded three versions of the ending, giving viewers 24 hours to vote on which one will make the final cut.

Other companies are also hopping on the social bandwagon:?

Doritos has reprised its annual "Crash the Super Bowl" contest, allowing a fan-made commercial to air during the game.?
Lincoln has teamed up with Jimmy Fallon to let fans write the script for its commercial on Twitter with the hashtag #Steerthescript.?
Pepsi, Pizza Hut and Toyota will include fan-submitted photos in a commercial.?
VW is promoting the #GetHappy hashtag.

Advertisers still have plenty of tricks up their sleeves, though, and some are deliberately taking an "anti-leak" strategy that still has an eye on Twitter impact.

"Some advertisers are holding back ads for a 'surprise' factor and for the instant chatter that will take place on social media during the game," said Katherine Wintsch, founder of The Mom Complex, an Interpublic Group of Companies unit focused on marketing to mothers.

Brands still place a premium on using the Super Bowl as the ultimate stage for product debuts; Anheuser-Busch is going to debut two new drinks at the game: Budweiser Black Crown and Beck's Sapphire.

"I don?t know what it is, but everyone finds humor in dog ads or baby ads," John Yorke, President of creative firm Rain 43, said. "Last year, we saw lots of both ? and the highest rated ads came from these categories ? so if it ain?t broke, don?t fix it ? expect to see more of this trend."?

Source: http://www.nbcnews.com/business/super-bowl-ads-its-go-viral-or-go-home-1C8119016

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Cosmetic Dentistry ? Blog Archive ? Improved Self Confidence ...

26 Jan 2013

Posted by admin

A smile makeover may be the best cosmetic change a person can make in himself or herself. Smile makeovers have the potential to transform a person?s entire body image because our smiles are so personal and make such powerful statements about our personalities and livelihoods.

If You Don?t Like Your Smile, You Won?t Smile
It will likely come as no surprise that a person?s self esteem is often inseparably linked to the quality of his or her smile. When two people meet for the first time, the smile is one of the first things noticed by either party. The eye is drawn to a smile because the mouth is one of the most expressive features of the human face. People with poor smiles caused by damaged, discoloured, or missing teeth are often less likely to participate in social activities, less likely to excel in work or school, and even less likely to develop meaningful relationships with other people. With all the advances made in modern dentistry, it isn?t necessary any longer for people to cope with the smiles they?ve been given. A smile makeover in London can dramatically transform one?s appearance, thereby improving self esteem and self image.

What Can Pendragon Do For Your Smile?
The customers who visit Pendragon Health in London often ask what the dental technicians and medical professionals can do to improve their smiles. The answer, of course, is that the opportunities for smile improvement are endless when customers are treated by physicians with the knowledge, experience, and equipment that the dentists at Pendragon have. There are hundreds of different types of cosmetic dentistry procedures that customers can use to improve their smiles.

The smile makeover cost is often the one thing that consumers have trouble with. However, customers are often surprised to find that the costs are much lower than what they expected. This is why Pendragon offers free consultations to prospective customers. Those who want a dramatic smile makeover in Holborn can come in and have questions answered, so they will know precisely what to expect during and after a surgical dental procedure.

Source: http://www.pendragonhealth.co.uk/blog/improved-self-confidence-linked-to-smile-makeover/

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Olympic Torch lights up Sligos Peace Mini Olympics : Sligo Sport ...

An Olympic torch was the highlight of Sligo?s Mini Olympics last week (4th ?Dec) when 100 primary school pupils took part in non-competitive games organized by Sligo Sports and Recreation Partnership. The Sligo Mini Olympics are designed to increase awareness and understanding of cultural diversity and encourage inclusive celebration among young people.

sligo-mini-olympics-low-res-3011

The Sligo Mini Olympics are funded by the PEACE III Programme through the European Union?s European Regional Development Fund managed for the Special EU Programmes Body by Sligo County Council on behalf of Sligo Peace and Reconciliation Partnership Committee. They were organized by Sligo Sport and Recreation Partnership, which is part of the Urban Peace Collective, a project of the PEACE III programme.

The Olympic torch was brought to Sligo by the Irish Sports Council Sports Partnership Officer Michelle Harte, who was a special guest at the event.

Five primary schools, Our Lady of Mercy P.S, St Edward?s N.S, St Brendan?s N.S, St John?s School and Sligo School Project took part in the Mini Olympics. Children at each school received coaching sessions in preparation for the event. Each school represented a country at the Mini Olympics and developed its own flags and banners for the event.

The young athletes took part in hurdles, speed bounce, javelin, hammer, long jump and rebounder relays in mixed teams with pupils from other schools, without the focus of competition.

?Sligo Sport and Recreation Partnership were delighted to have Michelle Harte from the Irish Sports Council as our special guest. The Olympic Games are the world?s greatest multi-cultural sporting spectacle and are a means to inspire, stimulate and promote positive messages and good practice through sport,? said Diane Middleton of Sligo Sports and Recreation Partnership.For further information on this initiative please contact Diane Middleton, Sligo Sport and Recreation Partnership on 071-9161511 or email diane@sligosportandrecreation.ie.

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Source: http://www.sligosportandrecreation.ie/2013/01/olympic-torch-lights-up-sligos-peace-mini-olympics/

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Immune cell suicide alarm helps destroy escaping bacteria

Friday, January 25, 2013

Cells in the immune system called macrophages normally engulf and kill intruding bacteria, holding them inside a membrane-bound bag called a vacuole, where they kill and digest them.

Some bacteria thwart this effort by ripping the bag open and then escaping into the macrophage's nutrient-rich cytosol compartment, where they divide and could eventually go on to invade other cells.

But research from the University of North Carolina School of Medicine shows that macrophages have a suicide alarm system, a signaling pathway to detect this escape into the cytosol. The pathway activates an enzyme, called caspase-11, that triggers a program in the macrophage to destroy itself.

"It's almost like a thief sneaking into the house not knowing an alarm will go off to knock down the walls and expose him to capture by the police," says study senior and corresponding author Edward Miao, PhD, assistant professor of microbiology and immunology at UNC. "In the macrophage, this cell death, called pyroptosis, expels the bacterium from the cell, exposing it to other immune defense mechanisms."

A report of the research appears online in the journal Science on Thursday January 24, 2013.

Miao, also a member of the UNC Lineberger Comprehensive Cancer Center, says the new findings show that having this detection pathway protects mice from lethal infection with the type of vacuole-escaping Burkholderia species: B. thailandensis and B. pseudomallei.

Both are close relatives. But they differ in lethality. B. pseudomallei is potentially a biological weapon. Used in a spray, it could potentially infect people via aerosol route, causing sickness and death. Moreover, it also could fall into a latent phase, "essentially turning into a 'sleeper' inside the lungs and hiding there for decades," Miao explains. In contrast, B. thailandensis, which shares many properties with its species counterpart, is not normally able to cause any disease or infection

These environmental bacteria are ubiquitous throughout S.E. Asia, and were it not for the caspase-11 pathway defense system, that part of the world could be uninhabitable, Miao points out.

This grim possibility clearly emerged in the study. Mice that lack the caspase-11 detection pathway succumb to infection not only by B. pseudomallei, but also to the normally benign B. thailandensis. "Thus caspase-11 is critical for surviving exposure to ubiquitous environmental pathogens," the authors conclude.

Miao points to research elsewhere showing that the pathway's abnormal activation in people with septic shock, overwhelming bacterial infection of the blood, is associated with death. "We discovered what the pathway is supposed to do, which may help find ways to tone it down in people with that critical condition.

As to bioterrorism, the researcher says it may be possible to use certain drugs already on the market that safely induce the caspase-11 pathway. "Since this pathway requires pre-stimulation with interferon cytokines, it is conceivable that pre-treating people with interferon drugs could ameliorate a bioterror incident. This could be quite important in the case of Burkholderia, since these bacteria are naturally resistant to numerous antibiotics.

"But first we have to find out if they would work in animal models, and consider the logistics of interferon stockpiling, which are currently cost prohibitive."

###

University of North Carolina Health Care: http://www.med.unc.edu

Thanks to University of North Carolina Health Care for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126466/Immune_cell_suicide_alarm_helps_destroy_escaping_bacteria

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Saturday, January 26, 2013

The Daily Roundup for 01.25.2013

You might say the day is never really done in consumer technology news. Your workday, however, hopefully draws to a close at some point. This is the Daily Roundup on Engadget, a quick peek back at the top headlines for the past 24 hours -- all handpicked by the editors here at the site. Click on through the break, and enjoy.

Pebble smartwatch review

After $10 million in funding from Kickstarter, Pebble finally ships to backers, and us...

The Engadget Interview

Don't ask, don't get. That's why we rang up Canonical and requested an early build of Ubuntu for the Galaxy Nexus. (Politely declined.) Next, we asked if maybe the company could speed up development...

Apple drops supplier over underage labor

Apple's latest Supplier Responsibility Report has just been published...

Distro Issue 75

Ever wanted to take off and soar the friendly skies...

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/M1Eyo9ZssvI/

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Venezuela VP: ailing Chavez in 'best moment'

CARACAS, Venezuela (AP) ? Venezuelan President Hugo Chavez's condition has improved and he is now optimistic as he faces more treatment following cancer surgery, his vice president said Saturday.

Vice President Nicolas Maduro said after meeting with Chavez in Cuba that the ailing president is now "in the best moment we've seen him in these days of struggle" following his Dec. 11 cancer surgery. Chavez hasn't appeared or spoken publicly since before the operation, and his government has said he suffered complications including a severe respiratory infection but has recently been improving.

Maduro spoke on state television early Saturday after returning from Havana to Venezuela. He said he was leaving shortly for a summit meeting in Chile with a written message from Chavez.

"We're taking a message prepared by the president, and we're going to turn it over to heads of state who attend the CELAC summit. He makes fundamental proposals," Maduro said, adding that the message was in Chavez's handwriting.

Maduro said Chavez also sent a message for Venezuelans, including that he was "very optimistic" about his treatment. Maduro said Chavez is "hanging on to Christ and to life."

Maduro said Chavez also urged his supporters in Venezuela to be alert about opponents seeking to do harm to his socialist-oriented "revolution." However, Maduro didn't elaborate.

The vice president, whom Chavez designated as his successor before the operation, spoke on television surrounded by officials including Defense Minister Diego Molero and Information Minister Ernesto Villegas. Maduro said Villegas would give a more detailed update on Chavez's health later Saturday.

Chavez has undergone repeated surgeries, chemotherapy and radiation treatment for an unspecified type of pelvic cancer. He has undergone much of his treatment in Cuba.

The 58-year-old president won re-election in October, and lawmakers indefinitely put off his inauguration earlier this month in a decision that was condemned by opponents but upheld by the Supreme Court.

The vice president said that Chavez "has reviewed and evaluated reports on different areas and has made decisions."

He said Chavez evaluated the country's economic situation and budget and made decisions about gold reserves, funding for public housing projects and "social investments and economic development." Maduro didn't give more details but said the actions approved by the president were intended to "guarantee the country's economic growth, infrastructure, housing."

Maduro said that one of the documents signed by Chavez dealt with the selection of his socialist party's candidates for mayoral elections later this year. The vice president showed the signature in red ink on one of the documents.

Source: http://news.yahoo.com/venezuela-vp-ailing-chavez-best-moment-072401926.html

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Friday, January 25, 2013

Mesothelioma Lawsuit News on proposed rule changes | Seedol.com

Mesothelioma Lawsuit News

01/25/2013? Mesothelioma Lawsuit News and Information:? Recent proposed legislation in the U.S. Congress as well as several states could make it more difficult for? Mesothelioma Lawyers who represent individuals who were exposed to asbestos and developed Mesothelioma Cancer to receive compensation in a timely manner. If you or a family member? has been diagnosed with mesothelioma, asbestos or lung cancer related to asbestos exposure,? you should take action to file your Mesothelioma Lawsuit or other Asbestos Lawsuit as soon as possible. Please call the toll free number on this page or use the contact form to get more information on filing a Mesothelioma Lawsuit or other? asbestos cancer related lawsuit.

Mesothelioma Litigation becomes more difficult of

Mesothelioma Lawyers

If the laws and rule changes being circulated before Congress and several state legislatures pass it could become more difficult for Mesothelioma Lawyers to get compensation for their clients in a timely manner. None of the proposed rules or laws will eliminate Mesothelioma Lawsuits or the liability of employers that exposed employees to asbestos that resulted in those employees developing Mesothelioma cancer or other asbestos cancers.

The effect of the proposed laws and rules would be to make the Mesothelioma Lawsuit process more cumbersome and difficult than it already is.? Most of the rules and laws being considered are directed at Mesothelioma or Asbestos trust funds that have been established from the assets of companies that are no longer in business that previously exposed their employees to asbestos. Currently these Mesothelioma Trust Funds? have tens of billions of dollars in trust to pay mesothelioma lawsuit and other asbestos lawsuit claims for victims when the employer that exposed them to Asbestos is no longer in business.? Even if? the defendant in a Mesothelioma Lawsuit is still in business and no compensation is being sought from the Mesothelioma Trust Funds , Mesothelioma Lawyers will still have to undertake processes that they did not have to previously go through to get compensation for their clients Mesothelioma Claims.

Mesothelioma Lawsuit Statute of Limitations

Time Limits already exist for filing Mesothelioma Lawsuits, these time limits can be affected by a number of factors. The time limits to file a Mesothelioma Lawsuit are called Statute of Limitations. A victim of Mesothelioma or another asbestos cancer has always been well advised to speak to a Mesothelioma Lawyer and being the Mesothelioma Lawsuit process as soon as they realize they have an asbestos related cancer.? With the new Mesothelioma Laws and rules being proposed, it may be more important than ever that a Mesothelioma Cancer victim act quickly to being the process of filing a Mesothelioma Lawsuit

For additional information on Mesothelioma Lawsuits visit http://www.mesothelioma.law.pro

Technorati Tags: Mesothelioma Lawsuit, mesothelioma lawsuits, Mesothelioma Lawyer, mesothelioma lawyers

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Source: http://www.seedol.com/blog/2013/01/25/mesothelioma-lawsuit-news-on-proposed-rule-changes-946/

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Blogging: A Business Model for Growth - Social Media Examiner

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Source: http://www.socialmediaexaminer.com/blogging-a-business-model-for-growth/

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Police arrest man in Syria kidnap investigation

LONDON (Reuters) - Police arrested a 31-year-old in London under anti-terrorism laws on Thursday as part of an investigation into the kidnapping of two European photographers in Syria last July.

The man, who was not named, will be charged with the "preparation of terrorist acts" when he appears in court in London on Friday morning, the Metropolitan Police said in a statement.

British police have been involved in an investigation into the kidnap of two photographers taken hostage near the Syrian border with Turkey last July 17. Jeroen Oerlemans from the Netherlands and his British colleague John Cantlie were released on July 26.

British police had first arrested the man on January 10 and freed him without charge six days later, the statement added. Two other men have already been charged in connection with the same investigation.

Police did not give the arrested man's nationality or more details of the allegations against him. A Metropolitan Police spokesman would not comment further.

About 60,000 Syrians have been killed in an uprising against President Bashar al-Assad that began nearly two years ago.

(Reporting by Peter Griffiths; Editing by)

Source: http://news.yahoo.com/police-arrest-man-syria-kidnap-investigation-212949628.html

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